CV - Curriculum Vitae

Short bio

Born in Bragança (Portugal) in 1971 I grew up in Cascais where I still live with my (body&soul) mate + a clutch of the 4 most beautiful embryos ever produced (Dé, Dany, JP & Bá)! Growing up, summers were often spent in the countryside in Bragança in contact with nature...naturally I became a Biologist! Graduated in Biology in 1994 from  the Fac. Sciences Univ. Lisbon, I followed a post-graduation in Dev Biology from Lusofona Univ, studying gastrulation in sea urchins. In 2004 I finished my PhD in Anatomy and Cell Biology from the School of Medicine and Biomedical Sciences of the State University of New York, at Buffalo NY - USA studying cell migration in 3D. As an undergrad I also lectured in high-schools, and during my PhD worked part-time as assistant of Confocal Microscopy Lab of SMBS/SUNY-Buffalo. In 2004 I returned to Portugal to teach Dev Biology at the Instituto Piaget - Almada and started a post-doc at FCUl in 2006. In 2008 I became an auxiliary researcher at the Centre for Environmental Biology (CBA/FCUL), during which I served also as a member of the Executive Committe (2009-2010), and as manager of the FCUL's Microscopy FacilityI have authored articles and book chapters on developmental and cell biology and Bioimaging, created (and still run) FCULs master’s course on Bioimaging, and have participated and organized several national and international advanced courses on microscopy. Currently I am the head of the "Advanced Imaging" facility of the  Instituto Gulbenkian de Ciencia in Oeiras. Outside science I'm interested in rock music, photography, home-improvement, mechanics and spending time with our brood.

Gabriel José Gonçalves Martins

Instituto Gulbenkian de Ciência
R. Quinta Grande, 6
2780-156 Oeiras
Tel: +351 214464539 
email: gaby@igc.gulbenkian.pt

Academic degrees
  • 2004 - PhD in Anatomy & Cell Biology; School of Medicine & Biomedical Sciences,  SUNY Buffalo, USA
  • 1997 - Post-grad Dev. Biology; Univ. Lusófona, PT
  • 1994 - Licenciature in Biology, Faculdade de Ciências, Univ. Lisboa
Professional experience
    Other qualifications
  • Reviewer for journals of cell biology, anatomy/embryology, microscopy and methods (11) 
  • Scientific Review Panel for CORBEL and COST actions
  • Laser safety officer - certified by adLaser
  • Animal Experimentation certification (FELASA catC)
  • Optical Microscopy and Imaging in the Biomedical Sciences course, Woods-Hole, 2002
  • 1st year of Licenciature in "Information Technology and Management" by  Universidade Moderna, 1995
  • Scientific Illustration (120h) by Sociedade Pt. Biologia, 1992
   Experience as scientific advisor:
  • Catarina Bota (CEDOC/IGC - co-adviser) MsS practicum, 2017-2018
  • Maria Rita Pegado (IGC); PhD practicum, 2018
  • Ana Couto (FCUL, Lab Marítimo da Guia; co-advisor with Rui Rosa). Practicum, 2015
  • Ânia Gonçalves (IGC). IEFP practicum, 2015-2016
  • Ricardo Araújo (IGC); PhD practicum, 2014
  • Nelson Nhamutole (IGC & Mozambique). MsS practicum, 2014-2015
  • Pedro Almada (FCUL). MsS practicum, 2012
  • Ana Raquel Jacinto (FCUL). MsC Thesis "The role of N-cadherin in chick somitogenesis" 2011
  • Joana Mateus (FCUL). MsC Thesis "Effect of polyploidy in the development and epigenetics in S. alburnoides" 2011
  • Tomás Azevedo (FCUL). MsC Thesis "Dynamics axis elongation in amniotes vs. anamniotes: Role of notochord" 2009.
  • António Temudo (FCUL). MsC Thesis "Mecânica e Mecanismos de Somitogénese Embriões de Vertebrados" 2008.
  • Rita Amândio (FCUL). MsC Thesis "Morphodynamics of somite epithelialisation in chick embryos" 2008.
    Participation on Jury committees
  • Marina Fridman 2019 (PhD, CCU/FC)
  • Telmo Pereira, 2017 (PhD, UNL)
  • Ana Russo, 2016 (Masters, FCUL)
  • Margarida Parente, 2016 (PhD, ITQB/FCT-UNL)
  • Sergio Cardoso, 2015 (Masters, FCT-UNL)
  • Susana Gomes, 2013 (PhD thesis, FCT-UNL)
  • Cláudia Aragão, 2012 (Licenciature, FCT-UNL)
  • Ricardo Henriques, 2011 (PhD thesis, FMUL)
  • Pedro Lopes, 2011 (Masters, FCUL/IGC)
  • Pedro Silva, 2011 (Masters, FCUL/IGC)
  • Cláudia Mendes, 2010 (Masters, FCUL/IMM)
  • Joana Lima, 2010 (Masters, FCUL/IMM)
    Organization of scientific events (last 5y)
Recent grants & awards (last 5y)

    Grants as PI/proponent or with coordination roles (links here)
  • FCT "OPenT & IMAGIOLOGIA MESOSCÓPICA MULTIMODAL" ref 02/SAICT/2017 (PI) 240K€ 
  • FCT ROTEIRO/0076/2013. “PPBI - Portuguese Platform for Bioimaging”. 2017-2020. Roteiro Nacional de Infraestruturas de Investigação de Interesse Estratégico (co-coordinator). 5.2M€
  • COST action CA15124 NEUBIAS - A new Network of European BioImage Analysts to advance life science imaging (co-proponent and WG2 leader) 2015 746K€
    Participation in grant projects (links here)
  • FCT Proj soluções inovadoras - COVID-19 #580  "A practical assay for routine detection of neutralizing antibodies against SARSCoV2 that bypasses requirements for high biosafety laboratory usage"; 2020 (participant) 40k€
  • PTDC/AAG-GLO/1926/2014 SHARKFIT: Impactos das alterações climaticas no incio da ontogenia de tubarões temperados e tropicais (participant) 150K€
    Awards

Scientific contributions

My first scientific project was to fully 3D reconstruct early sea-urchin embryos and show that GI tract extension involves increase in number of cells, and  not simply rearrangements (1 paper). I then studied cell migration in vitro and we demonstrated that mechanisms of endothelial cell migration in 3D matrices differs significantly from those observed in conventional 2D cultures, and that microtubules play an important role in regulating cell-matrix interactions, crucial for migration in 3D (2 papers). Working in somitogenesis, we produced the first 3D movies of chick somite formation and discovered a plethora of cellular movements and morphogenetic processes spanning well beyond the period of one clock cycle in chick (1 paper), and showed that the ECM plays important roles in instructing and containing cells during somite formation and their transformation into muscle, both in vivo and in vitro (3 papers). Other ongoing works include the study of somitogenesis and the dynamics of axis extension in amniotes vs anamniotes, the effect of poliploidy in early development of a naturally occurring iberian species of polyploid fish (3 posters), the description of developmental stages of non-model species, the anatomical description of fossil samples imaged through synchrotron and microCT imaging (1 paper), and the use of artificial matrices in cell culture for tissue engineering (2 papers). 
More recently I demonstrated how to implement optical tomography with fully open-source tools (OPenT), and participated in the development of the OpenSPIN Microscopy platform, which allows construction of systems like optical tomography and light-sheet (3 publications).
I created and maintain the "Haeckaliens" site (http://www.gabygmartins.info/research/haeckaliens), where optical tomography images of non-model species embryos are shared openly. One of these images received the 1st prize in the Nikon small world video competition in 2013!

Recent publications

        IDs & metrics:

    Peer reviewed publications
  • Gabriel G Martins, Alexandre Lopes, Hugo Pereira, Nuno P Martins, Sebastian Munck, James Swoger 2020 (in print). "OPT – Optical Projection Tomography" in Imaging Modalities for Biological and Preclinical Research: A compendium. Ed:Andreas Walter, Julia Mannheim and Carmel Caruana (https://iopscience.iop.org/bookListInfo/physics-engineering-medicine-biology-series)
  • Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M. A 2020. A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. eLife.  https://doi.org/10.7554/eLife.56615  and  bioRxivhttps://doi.org/10.1101/2020.03.09.983809

  • Campinho MA, Silva N, Martins GG, Anjos L, Florindo C, Roman-Padilla J, Garcia-Cegarra A, Louro B, Manchado M, Power DM, 2018. A thyroid hormone regulated asymmetric responsive centre is correlated with eye migration during flatfish metamorphosis. Scientific reports 8: 12267-  https://doi.org/10.1038/s41598-018-29957-8
  • R Gorgulho, R Jacinto, SS Lopes, SA Pereira, EM Tranfield, GG Martins, Emilio J. Gualda, Rico J. E. Derks, Ana C. Correia, Evelyne Steenvoorden, Petra Pintado, Oleg A. Mayboroda, Emilia C. Monteiro & Judit Morello 2018. Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations. Archives of Toxicology, 9:410-423 https://doi.org/10.1007/s00204-017-2063-1

  • A Jerónimo, G Rodrigues, F Vilas-Boas, GG Martins, A Bagulho, C Real 2017. Hydrogen peroxide regulates angiogenesis-related factors in tumor cellsBiochem & Cell Bio 95: 679-85 https://doi.org/10.1139/bcb-2017-0083
  • Sérgio Ferreira-Cardoso, Ricardo Araujo, Nelson Martins, Martins GG, Stig Walsh, Rui Martins, Nikolay Kardjilov, Ingo Manke, André Hilger, and Rui Castanhinha (2017). Floccular fossa size is not a reliable proxy of ecology and behaviour in vertebrates". Scientific Reports. https://doi.org/10.1038/s41598-017-01981-0
  • Gualda, E.J., Pereira, H., Martins GG, Gardner, R., Moreno, N. (2017). Three-dimensional imaging flow cytometry through light-sheet fluorescence microscopy. Cytometry part Ahttps://doi.org/10.1002/cyto.a.23046
  • Susana Gomes, Gabriela Rodrigues, Martins GG, Célia Henriques, Jorge Carvalho Silva (2017).  Evaluation of nanofibrous scaffolds obtained from blends of chitosan, gelatin and polycaprolactone for skin tissue engineeringInt J Bio Macromol. 102: 1174–1185 https://doi.org/10.1016/j.ijbiomac.2017.05.004
  • Kota Miura, Julien Colombelli, Fabrice Cordelières, Perrine Paul-Gilloteaux, Sébastien Tosi, Clara Prats Gavalda, Sebastian Munck, Julia Fernandez-Rodriguez, Gabriel G. Martins. 2017. NEUBIAS Conference in Lisbon: A New Venue for Bioimage Analysts. G.I.T. Imaging & Microscopy 3: 8-9 (no IF for 2017).

  • Felix PM, Gonçalves A, Vicente JR, Fonseca PJ, Amorim MCP, Costa JL, & Martins, GG (2016). Optical micro-tomography “OPenT” allows the study of large toadfish Halobatrachus didactylus embryos and larvae. Mech of Develop. doi:10.1016/j.mod.2016.03.001
  • N Lebesgue, G Costa, RM Ribeiro, C Ribeiro-Silva, GG Martins, V Matranga, A Scholten, C Cordeiro, AJR Heck, R Santos, 2016. Deciphering the molecular mechanisms underlying sea urchin reversible adhesion: A quantitative proteomics approach. Journal of Proteomics 138: 61-71  https://doi.org/10.1016/j.jprot.2016.02.026
  • Parente MR,  Monteiro JT,  Martins GG, Saraiva LM (2016). Helicobacter pullorum induces in murine macrophages nitric oxide release that promotes phagocytosis and killing. Microbiology https://doi.org/10.1099/mic.0.000240
  • Vilas-Boas F, Bagulho A, Tenente R, Teixeira VH, Martins GG, da Costa G, ... & Real C (2016). Hydrogen Peroxide regulates Cell Adhesion through the Redox Sensor RPSA. Free Radical Biology and Medicine 90:145-157 https://doi.org/10.1016/j.freeradbiomed.2015.11.019

  • Zeng, W., Pirzgalska, R. M., Pereira, M. M., Kubasova, N., Barateiro, A., Seixas, E., ... & Domingos, A. I. (2015). Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis. Cell 163: 84-94 https://doi.org/10.1016/j.cell.2015.08.055
  • Gomes SR, Rodrigues G, Martins GG, Roberto MA, Mafra M, Henriques CMR, Silva JC 2015. In vitro and in vivo evaluation of electrospun nanofibres of PCL, chitosan and gelatin: A comparative study. Mat Sci & Eng: C. https://doi.org/10.1016/j.msec.2014.10.051
- 5 relevant papers (>5y)
  • Mendes R, Martins GG, Cristóvão A, Saúde L 2014. Asymmetric N-cadherin locks left-right asymmetry by stopping leftward cell movements at Hensen’s node. Dev Cell 30:353–360 https://doi.org/10.1016/j.devcel.2014.06.010
  • Ruparelia AA, Simkin JE, Salgado D, Newgreen DF, Martins GG, Bryson-Richardson RJ. 2014. The quail anatomy portal. Database (Oxford). 7;2014- https://doi.org/10.1093/database/bau028
  • Gualda E, Moreno N, Tomancak P, Martins GG 2014. Going "open" with Mesoscopy: a new dimension on multi-view imaging. Protoplasma 251:363-. https://doi.org/10.1007/s00709-013-0599-3
  • Emilio J Gualda, Tiago Vale, Pedro Almada, José A Feijó, Gabriel G Martins & Nuno Moreno 2013. OpenSpinMicroscopy: an open-source integrated microscopy platform. Nature Methods https://doi.org/10.1038/nmeth.2508
  • Martins GG, Rifes P, Amândio R, Rodrigues G, Palmeirim I, Thorsteinsdóttir S. 2009. Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis. PLoS One 4(10):e7429. https://doi.org/10.1371/journal.pone.0007429

Recent Communications (seminars, lectures, workshops)
    
  • COMULIS CLEM School - Portugal 2020
  • Harmonious Meeting, COST - Portugal 2019
  • EuroBioimaging Meeting - EMBL 2019
  • SPAOM - Portugal 2019
  • INL - Portugal 2019
  • CoolTools - Champalimaud F. 2019 (1st prize cool tool)
  • MiFoBio - community workshop 2018
  • COST workshop - Belgium, 2018
  • CNC, Univ Coimbra. - Portugal, 2018.
  • FOM 2017, Bordeaux - France, April 2017
  • Plant Imaging workshop, Univ Maryland USA, April 217
  • International Symposium in applied Bioimaging. 2016 October 16-17, Porto
    Communications in poster format in last 5y: 19